New Orleans is known for its vibrant culture, bold colors, and artistic flair—so ... to make sure the more than 5,000-square-foot house didn’t just look cool but felt inviting and fun.

When Seamus McGuire first toured this 1910 home in the Touro/Bouligny neighborhood of New Orleans, he saw something that other potential buyers did not. "A lot of people passed on the house," he says.

The rainbow-colored residence features several paintings by the artist, a walk-in wine cellar, and a swimming pool.