The investigators then demonstrated that the dysregulation of this metabolic pathway led to increased lipid peroxidation—a process that damages cellular membranes and may trigger neuronal death.

The ROS (reactive oxygen species), which is generated from hydrogen peroxide can lead to lipid peroxidation. It is a chain reaction, which can damage cell membranes, disrupt membrane integrity ...

The key cyclization of an allylic alkoxyl radical to a carbon-centered allylic radical had been detected earlier (3) and has subsequently been recognized as a "key step in hydroperoxide-amplified ...