Initiation of dosing in our Phase 1b clinical trial represents an important step in the clinical development of GT-02287 and in Gain’s mission to deliver a disease-modifying therapy to people with ...

The research of D. Fernando Estrada, PhD, associate professor of biochemistry, has been recognized by the American Society for Pharmacology and Experimental Therapeutics (ASPET).

NEW YORK--(BUSINESS WIRE)--Allosteric Bioscience ... The licensed technology covers the use of inhibitors of an enzyme termed GCPII (glutamate carboxypeptidase II) for the treatment of sarcopenia.

Allosteric effectors that are not competitive can serve as effective activators of weak enzymes or as inhibitors of overactive enzymes. Allosteric activators or inhibitors induce small ...

Enzymes can be regulated by various means, such as allosteric regulation (binding of effector molecules), covalent modification (e.g., phosphorylation), and changes in pH or temperature. The Michaelis ...

The biochemical functions of proteins invariably involve interactions with ligands of some type, which act as enzyme substrates or inhibitors, signaling molecules, allosteric modulators ...

The orally administered, brain-penetrant small molecule is an allosteric enzyme modulator that restores the function of the lysosomal enzyme glucocerebrosidase (GCase) which becomes misfolded and ...

The orally administered, brain-penetrant small molecule is an allosteric enzyme modulator that restores the function of the lysosomal enzyme glucocerebrosidase (GCase) which becomes misfolded and ...