and Furuichi et al., revealed that certain viral and eukaryotic mRNAs have a cap — a methylated guanosine residue linked to the 5′ end of mRNA through an inverted 5′ to 5′ triphosphate bridge.

The updated mRNA-1273.815 COVID-19 vaccine was significantly protective against hospitalization and medically attended outcomes among adults in the United States.

We therefore investigated both the immunological memory elicited by mRNA vaccination against the Timothy grass pollen allergen Phl p 5, as well as the effect of repeated challenge with aerosolized ...

The mRNA cap structure is an important point of consideration for the immunogenicity of your mRNA-based product. Whereas legacy cap analogs produce a Cap0 structure and are recognized by the immune ...

The popularity of mRNA-based therapeutics has surged over the past few years. To ensure the safety of these treatments, scientists need to analyze the characteristics of the manufactured molecules, ...

kinetoplast mRNA editing) and under conditions of cellular stress (e.g., virus infection, unfolded protein response). RNA cleavage can occur either: (i) by a transesterification mechanism that yields ...