When the cardinals enter the Sistine Chapel on Wednesday at the start of conclave, the process of electing a new pope, they will be sealed off from the world.

A papal conclave blends the political and the spiritual, cardinals and theologians say. Here, in Catholic belief, is how the Holy Spirit fits in.

Cardinals will begin the crucial process of electing a new Pope. Join us as we explore the intricacies of the papal election and the frontrunners in this pivotal moment for the Catholic Church, live from Rome with Scripps News Correspondent Joe St.

Some cardinals are looking for a new pope who will continue with Pope Francis' push for a more welcoming Church, while others are seeking retrenchment to more traditional roots.

Two cardinals, Michael Czerny and Chibly Langlois, sat down with ABC News to discuss the challenges facing the church that the new pope will have to face.

Cardinals electing a new pope have some fundamental questions to weigh, beyond whether to give the Catholic Church its first Asian or African pope.