L'Isle-sur-la-Sorgue is a town and commune on the Sorgue river in Southeastern France. Politically, the commune is in the arrondissem…L'Isle-sur-la-Sorgue is a town and commune on the Sorgue river in Southeastern France. Politically, the commune is in the arrondissement of Avignon within the department of Vaucluse, in the région of Provence-Alpes-Côte d'Azur.